I ka makahiki 2021, ua hana kekahi mea maʻi kanesa pancreatic he 67 makahiki i kahi hana mana lapaʻau. Ma hope o ka ʻoki ʻana, nā manawa he nui o ka chemotherapy, a me ka hāʻule ʻana o ka lāʻau TIL, ua hoʻomaka ka hoʻokolohua lapaʻau o TCR-T.ʻO ka lāʻau lapaʻau cell āna i komo ai ua hoʻemi i ka metastases o ka māmā ma 72% i loko o 6 mau mahina. Ua paʻi ʻia kēia hopena holomua ma ka New England Journal of Medicine, e lawe mai ana i ka manaʻolana hou i nā poʻe maʻi me nā puʻupuʻu paʻa ma ka honua holoʻokoʻa.
Hiki i ke Kikowaena Kūkākūkā Honua o ka Halemai Oncology o Beijing South Suburb (400 - 880 - 3716) ke kūkulu i kahi alahaka i ka mālama olakino holomua honua no nā maʻi me kāna mau kumuwaiwai honua waiwai a he kuleana koʻikoʻi kāna i nā kūkākūkā honua a me ka mālama olakino.
E pili ana iā TCR-THoʻōla
TCR-TʻO ka cell therapy, ʻo ka inoa piha o ia hoʻi ʻo T - cell receptor engineered T - cell therapy, he ʻano hana immunotherapy cell adoptive hou. ʻO kona kumu nui ka unuhi ʻana i nā cell T mai ke kino o ka mea maʻi a hoʻokomo i ka gene TCR hiki ke ʻike i nā antigens tumor kikoʻī i loko o nā cell T ma o ka ʻenehana ʻenekinia genetic. ʻO ka hopena, hiki i nā cell T i hoʻololi ʻia ke ʻike pololei a hoʻopaʻa i nā antigens ma luna o nā cell tumor, no laila e hoʻoulu ai i ka hana pepehi ʻana o nā cell T a hoʻokō i ka pahuhopu o ka hoʻopau ʻana i nā cell tumor.
He Moʻolelo Holomua o TCR-TTherapy: Ka Hana Mana o kahi Maʻi me KRAS G12D - Mutated Pancreatic Cancer
Ma mua o ka ʻike ʻia ʻana he adenocarcinoma poʻo pancreatic, ua ʻeha nui kēia maʻi 67 makahiki ma muli o nā hoʻouka pinepine ʻana o ka pancreatitis a me ka biliary stricture. Ma hope o ka ʻike ʻia ʻana, ua hana ʻo ia i ʻehā mau pōʻaiapuni o ka regimen chemotherapy FOLFIRINOX neoadjuvant, a ukali ʻia e ka ʻoki ʻoki ʻana a laila chemotherapy hou aʻe. Ua hiki i kēia ke hoʻomalu ʻia kona kūlana no kekahi manawa, a ʻaʻole i holomua hou ka puʻupuʻu.
Eia naʻe, ʻaʻole i lōʻihi nā manawa maikaʻi. I ka makahiki 2019, ua loaʻa i ka mea maʻi nā metastases māmā, kahi mea i hoʻokūpaʻa nui i ka lāʻau lapaʻau. I ka makahiki 2020, ua komo ʻo ia i kahi hoʻokolohua lapaʻau o ka tumor - infiltrating lymphocyte therapy, akā ʻeono mahina ma hope mai, ua holomua hou nā ʻeha metastatic māmā, e hōʻike ana ʻaʻole hiki i nā ʻano lāʻau lapaʻau ma mua ke kāohi pono i ka ulu ʻana o ka tumor.
I ka wā i aneane pau ka manaʻolana o ka mea maʻi, i Mei 2021, ua ʻāpono ka US Food and Drug Administration i kahi noi noiʻi lāʻau lapaʻau hou, kahi i lilo i wahi hoʻololi koʻikoʻi i kona ola - ua hoʻolauna ʻia ʻo ia iā TCR-Tka lāʻau lapaʻau cell. I Iune 2021, ua loaʻa iā ia ka lāʻau lapaʻau autologous peripheral blood T-cell. ʻO ka mea kupanaha, hoʻokahi mahina ma hope o ka hoʻokomo ʻana o ke cell, ua emi nui nā ʻeha metastatic māmā o ka mea maʻi, a ua emi ka puʻupuʻu ma 62%. I ka hapalua makahiki wale nō ma hope mai, ua emi ka puʻupuʻu ma 72%.
Hōʻike piha kēia hopena therapeutic kupaianaha i ka hiki nui o TCR-Tka lāʻau lapaʻau cell i ka mālama ʻana i ka maʻi kanesa.
No nā poʻe maʻi kanesa, he mea koʻikoʻi ka loaʻa ʻana o kahi hōʻailona pololei a me ka hoʻolālā lapaʻau maikaʻi loa. Eia nō naʻe, ma muli o nā ʻokoʻa o nā pae lapaʻau a me nā ʻenehana ma nā wahi like ʻole, ʻaʻole hiki i nā mea maʻi ke loaʻa i ka ʻōlelo aʻoaʻo lapaʻau holomua loa ma kahi kūloko. Hāʻawi nā kūkākūkā honua i nā mea maʻi i kahi manawa kūpono e kamaʻilio me nā loea honua kiʻekiʻe, e hiki ai iā lākou ke aʻo e pili ana i nā ʻano lapaʻau hou loa a me nā hopena noiʻi ma ka honua holoʻokoʻa.
Ma o nā kūkākūkā honua, hiki i nā mea maʻi ke loaʻa nā loiloi multi-disciplinary mai nā loea mai nā ʻāina a me nā wahi like ʻole. Loaʻa i kēia mau loea ka ʻike lapaʻau waiwai a me ka ʻike ʻoihana a hiki iā lākou ke kālailai a hoʻokolokolo i ke kūlana o ka mea maʻi mai nā manaʻo like ʻole e hoʻomohala i nā hoʻolālā lapaʻau pilikino a pololei hoʻi.
Eia kekahi, hiki i nā kūkākūkā honua ke kōkua i nā mea maʻi e aʻo e pili ana i kekahi mau hoʻokolohua lapaʻau a me nā ʻano lapaʻau i hana ʻole ʻia ma Kina, e hāʻawi ana iā lākou i nā koho lapaʻau hou aku.
Ua ʻike maopopo ka ʻOihana Honua o ka Halemai ʻOncology ma Beijing South Suburb (400 – 880 – 3716) i ke koʻikoʻi o nā kūkākūkā honua no nā maʻi kanesa. No laila, ke kūkulu ikaika nei ia i kahi kahua hoʻololi lapaʻau honua e hāʻawi i nā mea maʻi me nā lawelawe kūkākūkā honua ʻoihana a maikaʻi hoʻi. Ma ka Halemai ʻOncology ma Beijing South Suburb, hiki i nā mea maʻi ke komo i nā kūkākūkā honua ma ka pūnaewele a i ʻole ma waho. E hōʻiliʻili kā mākou hui lapaʻau i nā moʻolelo lapaʻau o ka mea maʻi, nā hōʻike hoʻāʻo a me nā ʻike ʻē aʻe ma mua a unuhi iā lākou i ka ʻōlelo Pelekania e hōʻoia i ka hiki i nā loea honua ke hoʻomaopopo piha i ke kūlana o ka mea maʻi. I ka wā o ke kūkākūkā ʻana, e kamaʻilio maka nā loea honua me ka mea maʻi, e nīnau i nā nīnau kikoʻī e pili ana i ka mōʻaukala lapaʻau o ka mea maʻi, nā hōʻailona, a me ke kūlana lapaʻau, a laila e hoʻohui i nā hopena noiʻi lapaʻau hou loa a me ka ʻike lapaʻau e hoʻomohala i ka hoʻolālā lapaʻau kūpono loa no ka mea maʻi.
I ka manawa like, e hāʻawi pū ka ʻOihana Honua o ka Halemai Oncology o Beijing South Suburb i nā mea maʻi me nā lawelawe unuhi piha a me nā lawelawe hoʻonohonoho e hōʻoia i ka holomua mālie o ke kūkākūkā ʻana. Ma hope o ke kūkākūkā ʻana, e hāʻawi koke mākou i nā hopena kūkākūkā a me nā manaʻo lapaʻau i ka mea maʻi a hāʻawi i ke alakaʻi a me ke kākoʻo lapaʻau.
I mea e hiki ai i nā maʻi ke loaʻa i nā manaʻo hōʻailona a me nā manaʻo lapaʻau mai nā loea honua i ka wā hikiwawe loa, ua hoʻomaʻalahi ka International Department of Beijing South Suburb Oncology Hospital i ke kaʻina hana lawelawe kūkākūkā. Pono nā maʻi e kelepona i ka 400 - 880 - 3716 a hāʻawi i nā moʻolelo lapaʻau kūpono a me nā hōʻike hoʻāʻo. E hoʻonohonoho ka hui ʻoihana o ka International Department of Beijing South Suburb Oncology Hospital i kahi loea honua kūpono no ka mea maʻi e kūkākūkā i loko o ka manawa pōkole loa. I ka wā o ke kūkākūkā ʻana, e hōʻoia ka hui unuhi ʻoihana i ka kamaʻilio maʻalahi a pololei ma waena o nā kauka a me nā maʻi, e hiki ai i nā maʻi ke hoʻomaopopo pono i nā manaʻo a me nā manaʻo o nā loea. Eia kekahi, hiki i ka International Department of Beijing South Suburb Oncology Hospital ke kōkua i nā maʻi i ka lawelawe ʻana i nā kaʻina hana kuhikuhi, hoʻonohonoho i nā huakaʻi, a pēlā aku, e hāʻawi ana i nā lawelawe hoʻokahi.
Kaʻana like ʻana i nā hihia a me ka hoʻoulu manaʻo
Ma waho aʻe o ka hihia i luna o ka mea maʻi me KRAS G12D - ka maʻi kanesa pancreatic mutated, ua kōkua pū ka International Department of Beijing South Suburb Oncology Hospital i nā mea maʻi kanesa haole e hoʻokō i nā hopena lapaʻau maikaʻi ma o ka mālama ʻana ma Kina.
I Iune 2024, ua noi mai kekahi maʻi maʻi ʻaʻai māmā ʻaʻole liʻiliʻi mai Kōlea ʻĀkau i kā mākou kōkua. ʻO ke kanesa māmā kekahi o nā puʻupuʻu ʻino me nā helu hanana kiʻekiʻe loa ma ka honua holoʻokoʻa a ma Kina hoʻi. I ka makahiki 2022, aia ma kahi o 1.06 miliona mau hihia hou a ma kahi o 740,000 mau make mai ke kanesa māmā ma Kina, a ma waena o ia mau mea he 80% - 85% ka nui o ke kanesa māmā ʻaʻole liʻiliʻi (NSCLC).
Ua loaʻa i ka mea maʻi kahi hoʻololi EGFR a ua loaʻa iā ia nā lāʻau lapaʻau e like me afatinib a me osimertinib. ʻOiai ua loaʻa iā ia nā lāʻau lapaʻau like ʻole, ua hiki mai nō nā lono maikaʻi ʻole i Mei 2024, a ua holomua ke kūlana o ka mea maʻi. No laila, ua hele mai ʻo ia i Kina no kā mākou kōkua.
Ma hope o ka hoʻāʻo ʻana, ʻo ka hōʻike ʻana o ka mesothelin (MSLN) o ka mea maʻi he 75%. A laila ua kōkua mākou i ka mea maʻi e ʻimi i ka hoʻolālā lapaʻau hou loa ma ka ʻāina. I kēia manawa ua hōʻoluʻolu ʻia ke kūlana o ka mea maʻi, a ua emi nā nodules māmā, e like me ka mea i hōʻike ʻia ma ke kiʻi ma lalo nei.
Ke hōʻike mai nei kēia hihia iā mākou, no nā poʻe maʻi kanesa, ʻaʻole pono lākou e haʻalele maʻalahi i ka manawa kūpono no ka mālama ʻana. ʻOiai inā pilikia ka mālama ʻana ma ka home, hiki iā lākou ke hoʻomaopopo i nā ʻano lapaʻau honua hou loa a me nā hopena noiʻi ma o nā kūkākūkā honua a hoʻoikaika no nā manawa lapaʻau hou aʻe no lākou iho.
Pehea e hoʻokaʻaʻike aku ai i ka ʻOihana Honua o ka Halemai Oncology o Beijing South Suburb
Inā ʻoe a i ʻole kou ʻohana e ʻeha nei i ka maʻi kanesa a ke manaʻolana nei e aʻo e pili ana i nā ʻano lapaʻau holomua o ka honua a i ʻole e ʻimi i nā manaʻo no ka hōʻailona a me ka mālama ʻana mai nā loea honua, e ʻoluʻolu e kelepona i ka helu kelepona o ka International Department of Beijing South Suburb Oncology Hospital (400 - 880 - 3716). E pane ka hui ʻoihana i kāu mau nīnau, e hoʻonohonoho i nā kūkākūkā honua nou, a e hāʻawi iā ʻoe i ke kākoʻo a me ke kōkua āpau.
He kaua lōʻihi a paʻakikī ka mālama ʻana i ke kanesa, akā ke manaʻoʻiʻo nei mākou me ka holomua mau o ka ʻenehana lapaʻau, e hiki i nā poʻe maʻi kanesa ke lanakila i ka maʻi a hoʻihoʻi i ko lākou olakino. E hoʻomau ka International Department of Beijing South Suburb Oncology Hospital i ka hoʻoikaika e hoʻomaikaʻi mau i kāna pae lawelawe a me nā hiki lapaʻau a hāʻawi i nā lawelawe lapaʻau honua kiʻekiʻe no nā poʻe maʻi kanesa hou aku. E hana pū kākou e hakakā pū me ke kanesa a hana i nā hana mana o ke ola!
I kēia manawa, nui nā hoʻokolohua lapaʻau o nā ʻenehana anti-cancer hou ma Kina e ʻimi nei i nā maʻi. I ke kūkākūkā ʻana i nā lāʻau lapaʻau a me nā ʻenehana hou, hiki iā ʻoe ke hoʻokaʻaʻike aku i ka Beijing South Region Oncology Hospital International Department.
Helu Kelepona：4008803716
Email：myimmnet@163.com
Ka manawa hoʻouna: Mei-15-2025