Ua ʻike kekahi maʻi maʻi ʻaʻai lolo hope loa, ka mea i hoʻi hou i ka maʻi ma hope o 17 mau lāʻau CAR-T, ua nalo loa kāna puʻupuʻu i loko o 4 mau pule o ka loaʻa ʻana o kahi lāʻau lapaʻau TIL hou a ua noho ʻole ʻo ia i ka puʻupuʻu no nā mahina he 20 a ʻoi.
No nā nīnau e pili ana i nā lāʻau lapaʻau maʻi kanesa hou a me nā hoʻokolohua lapaʻau:
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Ua ʻike ʻia kekahi maʻi kāne 56 makahiki me ka glioblastoma lobe mua hema (IDH wild-type, WHO Grade 4, EGFR amplification)—ʻo ia kekahi o nā ʻano glioma o ka lolo ʻino loa a paʻakikī hoʻi e mālama.
Ma hope o ka hana ʻia ʻana o ka ʻoki ʻana i ka puʻupuʻu ma Ianuali 5, 2023, ua loaʻa mua iā ia ka lāʻau lapaʻau maʻamau, akā ua hoʻi hou kona kūlana ma hope o kahi manawa pōkole o ke kūpaʻa. Ma hope mai, ua hana ʻia ʻo ia i ka huina o 17 mau lāʻau lapaʻau CAR-T e pili ana i ʻelua mau antigens like ʻole, akā ua hoʻomau ka holomua o kona maʻi.
Me ka makemake nui, ua kākau inoa ʻo ia i kahi hoʻokolohua lapaʻau no kahi lāʻau lapaʻau TIL hou. He mea kupanaha nā hopena: 4 mau pule ma hope o ka hoʻokomo ʻana o nā cell TIL, ua hōʻike nā hoʻokolohua kiʻi ua hoʻopau loa ʻia ka puʻupuʻu i loko o kona lolo, a ua loaʻa kahi pane piha, a ua noho ʻo ia me ka ʻole o ka puʻupuʻu no nā mahina he 20 a ʻoi.
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Ke Kaua nei no ke Ola i kahi Kūlana Pōpilikia
Ua kapa ʻia ʻo Glioblastoma ʻo ia ka "mea pepehi kanaka intracranial helu ʻekahi." ʻO ka manawa o ka hōʻoia ʻana ua like ia me ka hoʻomaka ʻana o ka helu ʻana i ke ola.
Ma hope o ka ʻike ʻia ʻana o Mr. W, ua hana mua ʻia ʻo ia i kahi ʻoki ʻana i ka puʻupuʻu lolo kiʻekiʻe, a ukali ʻia e ka chemotherapy temozolomide a me ka radiotherapy. Eia naʻe, ʻaʻole i kaohi ʻia kona kūlana.
Ma hope mai, ua hoʻāʻo ʻo ia i ʻelua mau ʻano lapaʻau CAR-T like ʻole e pili ana i nā antigens like ʻole, e loaʻa ana ma mua o 10 mau inikini intratumoral i ka manawa like, akā naʻe, ʻaʻole naʻe i hiki ke hoʻōki i ka holomua o ka maʻi puʻupuʻu.
He palena ka hopena o nā lāʻau kuʻuna e kūʻē i ka glioma o ka lolo holomua. ʻOiai me nā hoʻolālā lapaʻau i hui pū ʻia e pili ana i ke ʻoki kino, radiotherapy, a me ka chemotherapy, ʻo ka awelika o ke ola holoʻokoʻa no nā maʻi ma kahi o 14.6 mahina wale nō.
I ke alo ʻana i ia kūlana manaʻolana ʻole, ua manaʻo nui ʻo Mr. W a me kona ʻohana i ka manaʻolana ʻole a hiki i ko lākou lohe ʻana e pili ana i ka hoʻokolohua lapaʻau TIL therapy.
TIL Therapy
ʻO ka TIL therapy, a i ʻole Tumor-Infiltrating Lymphocyte therapy, he hana immunotherapy cellular hou ia.
Hoʻomaka kēia lāʻau lapaʻau me ka ʻiʻo puʻupuʻu hou o ka mea maʻi ma ke ʻano he mea maka. Ma hope o ka hoʻokaʻawale ʻana, ka hoʻololi ʻana, a me ka hoʻonui ʻana i loko o ka vitro, hoʻokomo hou ʻia nā ʻāpana i loko o ka mea maʻi, e hoʻokō ana i ka lāʻau kūpono e "hakakā ana i ka puʻupuʻu me ia iho."
ʻAʻole e like me ka lāʻau lapaʻau CAR-T kuʻuna, ʻaʻole koi ka lāʻau lapaʻau GC101 TIL i ka lymphodepletion a i ʻole nā inikini IL-2, e hoʻomaikaʻi nui ana i ka palekana a me ka maʻalahi o ka lāʻau lapaʻau.
Hoʻomohala ʻia e Juncell Therapeutics, ʻo GC101 TIL therapy ka TIL kūlohelohe mua loa o ka honua e pono ʻole ai ka lymphodepletion a i ʻole ka inikini IL-2, me ka hoʻohana ʻana i kāna kahua hoʻonui cell DeepTIL® i hoʻomohala ponoʻī ʻia.
Ua hōʻike ʻia nā ʻikepili lapaʻau e kū nei he ʻoi aku ka nui o ka pane ʻana o GC101 ma mua o 35% e kūʻē i nā ʻano ʻōhū paʻa holomua. Ua loaʻa i kekahi mau maʻi ka hoʻopau piha ʻana i ka ʻōhū a me ka pane piha, me ka lōʻihi loa o ke ola ʻana me ka ʻole o ka ʻōhū ma mua o 3 mau makahiki.
Ke Kaʻina Hana Lapaʻau
I ka hopena o ka makahiki 2023, ua kākau inoa pono ʻo Mr. W i ka hoʻokolohua lapaʻau GC101 TIL.
Ua hoʻohana ka hui lapaʻau i nā pūnaewele TIL i hoʻoulu ʻia mai kāna hāpana ʻokiʻoki i loaʻa i hoʻokahi makahiki ma mua, kahi i mālama ʻia a hiki i ka wā e pono ai.
Ua hoʻonui pono ke kime lapaʻau i nā pūnaewele i ka huina o 2.95 × 10^10 mau pūnaewele TIL, me nā pūnaewele T e helu ana no 99.92% kiʻekiʻe o ka heluna kanaka, ʻo nā pūnaewele CD8⁺ T nui loa (97.85%).
Ma hope o ka hoʻomaʻamaʻa mua ʻana, ua loaʻa iā Mr. W ka hoʻokomo ʻana o nā cell TIL ma Dekemaba 12, 2023.
I ka wā o ka hoʻokomo ʻana, ʻaʻole i ʻike ʻo Mr. W i nā hopena koʻikoʻi, he kuni iki wale nō i emi koke. Ke hoʻohālikelike ʻia me nā lāʻau lapaʻau TIL kuʻuna, ua hōʻike kēia mana i hoʻololi ʻia i ka palekana kiʻekiʻe.
He Hoʻohuli Nui
He 4 mau pule wale nō ma hope o ka hoʻokomo ʻia ʻana o nā cell TIL, ua hōʻike ʻia nā hoʻokolohua kiʻi ma Ianuali 8, 2024, ua hoʻopau loa ʻia ka puʻupuʻu ma ka lolo o Mr. W.
ʻOi aku ka mea kupanaha, i ʻOkakopa 2025, ua mālama ka mea maʻi i ke ola ʻole ʻana mai ka puʻupuʻu no nā makahiki he 1.8 (i helu ʻia i ka manawa o ka hoʻokuʻu nūhou, ʻoi aku kēia ma mua o 20 mau mahina), e hoʻi hou ana i kahi ola maʻamau.
Hoʻonohonoho kēia hihia i kahi moʻolelo ola hou no ka glioblastoma hou a hāʻawi i nā hōʻike lapaʻau koʻikoʻi no ka hoʻolālā mālama ʻana o ka "laʻana ʻiʻo mua, TIL reinfusion ma luna o ka hoʻi hou ʻana."
E hōʻike ʻia kēia hoʻokō kupaianaha ma kahi pepa hoʻolaha ma ka Hālāwai Makahiki 40 o ka Society for Immunotherapy of Cancer, e mālama ʻia ana mai Nowemapa 7-9, 2025, e hōʻike ana i nā loea o ka ʻoihana honua.
Nā Manaʻolana e hiki mai ana
Ua hōʻike ʻo TIL therapy i ka hiki ke mālama ʻole i ka glioma o ka lolo akā ua hōʻike pū i ka hopena kupaianaha e kūʻē i nā ʻōpū paʻa ʻē aʻe e like me ka melanoma holomua a me ka maʻi kanesa māmā ʻaʻole liʻiliʻi.
I Pepeluali 2024, ua loaʻa i ka lāʻau lapaʻau TIL cell mua loa o ka honua, ʻo Lifileucel, ka ʻāpono FDA ma ʻAmelika Hui Pū ʻIa no ka mālama ʻana i nā maʻi me ka melanoma holomua i loaʻa mua i ka lāʻau lapaʻau PD-1 inhibitor.
I ka manawa like, ke hoʻolaha ikaika nei ʻo Kina i ka noiʻi lapaʻau ma ka lāʻau lapaʻau TIL. Ua ʻāpono ʻia ka hoʻokolohua lapaʻau hoʻopaʻa inoa Phase II koʻikoʻi no ka inikini GC101 TIL a Juncell Therapeutics e kuhikuhi ana i ka melanoma holomua e ke Kikowaena no ka Loiloi Lāʻau Lapaʻau o ka National Medical Products Administration.
Eia kekahi, ma ka lā 14 o ʻOkakopa, 2024, ua hoʻomaka kūhelu ʻia ka hoʻokolohua hoʻopaʻa inoa lāʻau lapaʻau TIL cell mua loa o Kina no ka maʻi kanesa o ka māmā, i manaʻo ʻia no ka mālama ʻana i ka maʻi kanesa o ka māmā ʻaʻole liʻiliʻi.
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I kēia manawa, nui nā hoʻokolohua lapaʻau no nā lāʻau lapaʻau anti-cancer hou a me nā ʻenehana ma Kina e ʻimi nei i nā maʻi.
Hāʻawi ka ʻOihana Hoʻokipa ʻOncology o ka ʻĀpana Hema ʻo Beijing i nā kūkākūkā e pili ana i nā lāʻau lapaʻau a me nā ʻenehana hou.
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Ka manawa hoʻouna: Nov-20-2025