Ma Pepeluali 9, 2026, ua hoʻolaha ka pūnaewele kūhelu o ke Center for Drug Evaluation (CDE) o ka National Medical Products Administration (NMPA) ua hoʻolālā ʻia ʻo ZL-1310 no ka injection, kahi DLL3-targeting antibody-drug conjugate (ADC) hou, e hāʻawi ʻia i ka Breakthrough Therapy Designation.
Ma ke ʻano he lālā o ka Peking University Cancer Hospital Medical Consortium a me kahi haukapila kūikawā oncology hou lua ma Beijing, hoʻohana ka Beijing South Region Oncology Hospital International Department i kahi kahua hōʻoia a me ka mālama ʻana i nā maʻi he nui e hoʻohui koke i kēlā mau ʻano lapaʻau alakaʻi honua i nā hoʻolālā mālama o nā maʻi o ka honua. Inā ʻoe a i ʻole kahi mea aloha e kū nei i nā pilikia o ka lāʻau lapaʻau lua a ma hope paha no ka maʻi ʻaʻai māmā liʻiliʻi, e ʻoluʻolu e heluhelu pono i ka ʻikepili ma lalo nei a e hoʻokaʻaʻike koke mai iā mākou.
E kāhea aku i ka ʻOihana Hoʻokele ʻĀina ʻo Beijing South Region Oncology Hospital International i kēia manawa:
- Kelepona: 400-880-3716
- Helu WeChat: 17801183037
- Email ①: 100085_010@163.com
- Email ②: myimmnet@163.com
**ʻIkepili Paʻakikī: A hiki i ka 86% Pono i nā Maʻi me nā Metastases o ka Lolo**
Ma ka Hālāwai Makahiki o ka American Society of Clinical Oncology (ASCO) 2025, ua hōʻike ʻia nā ʻikepili haʻawina lapaʻau honua pae 1a/1b no ZL-1310.
No nā poʻe maʻi i mālama mua ʻia (lāʻau lapaʻau laina lua):
- Ua hōʻea ka helu pane kūʻiʻo i hōʻoia ʻole ʻia (uORR) i ka 67%, me ka helu kaohi maʻi (DCR) o 97%.
- I loko o ka hui mahele lāʻau olaola kūpono loa (1.6 mg/kg): Ua piʻi aʻe ka helu pane pahuhopu (ORR) i 79%, me ka helu kaohi maʻi (DCR) o 100%.
- ʻO ke ʻano kēia: Ua loaʻa i kahi kokoke i nā maʻi he 10 i loaʻa i kēia mahele lāʻau ka kaohi ʻana i ka puʻupuʻu, a ua ʻike kahi kokoke i 8 mau maʻi i ka emi nui ʻana o ka puʻupuʻu.
No nā poʻe maʻi paʻakikī loa me nā metastases o ka lolo:
- Nā maʻi me nā metastases lolo kumu: ʻO ka helu pane pahuhopu (ORR) he 68%.
- Nā maʻi i loaʻa ʻole i ka radiotherapy cranial: ʻO ka helu pane pahuhopu (ORR) ua like me ke kiʻekiʻe a hiki i ka 86%!
He mea hou kēia ʻikepili. Ke hakakā nei nā lāʻau chemotherapy kuʻuna e komo i loko o ka pale koko-lolo, akā hōʻike ʻo ZL-1310 i ka hana anti-tumor ikaika i loko o ke koko. No nā poʻe maʻi honua e hopohopo nei e pili ana i nā hopena ʻaoʻao o ka radiotherapy o ka lolo holoʻokoʻa, hōʻike kēia i kahi manaʻolana koʻikoʻi o ka "pale ʻana i ka radiation lolo."
**ʻIke Palekana:** I loko o ka hui mahele lāʻau <2.0 mg/kg, ʻo ka nui o nā hanana ʻino e pili ana i ka lāʻau lapaʻau (TRAEs) o ka papa 3 a ʻoi aku paha he 6% wale nō, me ka ʻole o ka maʻi maʻi interstitial lung (ILD) e pili ana i ka lāʻau lapaʻau a i ʻole nā hanana hoʻōki lāʻau i hōʻike ʻia.
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**III. No ke aha e koho ai i ka ʻOihana Hoʻokele Honua o ka Halemai Oncology o ka ʻĀpana Hema o Beijing?**
No nā poʻe maʻi o ka honua, ʻo ke komo ʻana i nā lāʻau lapaʻau hou ʻaʻole wale ia e pili ana i ka "loaʻa ʻana o ka lāʻau," akā he kaʻina hana ʻōnaehana hoʻi e pili ana i ka "hiki ke hoʻohana, pehea e hoʻohana ai, a ʻo wai ka mea e mālama i nā hopena ʻaoʻao."
Hāʻawi ka ʻOihana Hoʻokele ʻĀina ʻo Beijing South Region Oncology Hospital International i nā loiloi e hiki mai ana a me ka hoʻokele piha ʻana no nā lāʻau lapaʻau hou e like me ZL-1310 no nā poʻe maʻi kūpono. Inā ʻoe mai Asia Hikina Hema, ka Hikina Waena, ʻEulopa, a i ʻole ʻAmelika, loaʻa iā mākou kahi kaʻina hana lawelawe lapaʻau honua i hoʻokumu maikaʻi ʻia.
Hāʻawi mākou i nā lawelawe piha mai nā kūkākūkā ma mua o ka haukapila, ka unuhi ʻōlelo ʻē aʻe, nā leka visa lapaʻau, a hiki i nā hahai ʻana i ka hoʻoponopono hou ʻana. ʻO ka mālama pono ʻana i ke kulekele "hoʻokahi kauka, hoʻokahi maʻi, hoʻokahi lumi" e hōʻoiaʻiʻo ana i kou pilikino a me kou hanohano e mahalo piha ʻia, ʻoiai ma kahi ʻāina ʻē.
I kēia manawa, ua hāʻawi ʻia ʻo ZL-1310 i ka Orphan Drug Designation a me ka Fast Track Designation e ka US FDA. ʻO kona hoʻolālā ʻia ʻana e hoʻokomo ʻia i loko o ka Breakthrough Therapy Designation o Kina e hoʻolalelale nui i kona hiki ke komo ma Kina.
Mai hoʻokuʻu i nā pale ʻōlelo, nā hakahaka ʻike, a i ʻole nā kaʻina hana paʻakikī e pale iā ʻoe mai ke komo ʻana i nā lāʻau lapaʻau holomua. Ua hoʻokumu ka ʻOihana Hoʻokipa ʻOncology o ka ʻĀpana Hema o Beijing i kahi ala ʻōmaʻomaʻo no nā poʻe maʻi o ka honua.
E kelepona mai iā mākou a i ʻole e leka uila mai iā mākou ma o WeChat a i ʻole leka uila e kaʻana like i kou kūlana. E hāʻawi kā mākou poʻe kākāʻōlelo lapaʻau i kahi loiloi mua i loko o 24 mau hola.
- Kelepona (kūkākūkā 24-hola): 400-880-3716
- WeChat (kamaʻilio koke): 17801183037 (kākoʻo i ka ʻōlelo Pelekania a me ka ʻōlelo Kina)
- Leka uila (no nā moʻolelo lapaʻau):
- 100085_010@163.com
- myimmnet@163.com
Ka manawa hoʻouna: Pepeluali-12-2026