Ma Malaki 31, 2026, ua hāʻawi ke Kikowaena no ka Loiloi Lāʻau Lapaʻau o ka ʻĀina Hoʻokele Huahana Lapaʻau Lahui o Kina i nā nūhou hoihoi: Ua hoʻokomo kūhelu ʻia ʻo GFH375, i hoʻomohala ʻia e GenFleet Therapeutics, ma ke ʻano he moho "Breakthrough Therapy" no ka mālama ʻana i nā maʻi me ka maʻi kanesa pancreatic metastatic me ka mutation KRAS G12D i loaʻa i ka liʻiliʻi o hoʻokahi lāʻau lapaʻau systemic ma mua. Hōʻailona kēia i kahi ʻanuʻu koʻikoʻi i mua i ke kahua o ka lāʻau lapaʻau pololei no ka maʻi kanesa pancreatic.
Inā ʻoe a i ʻole kahi mea aloha e hakakā nei me ka maʻi kanesa pancreatic KRAS G12D-mutant holomua, mai hoʻopau i ka manaʻolana. Ke hahai pono nei ka Beijing South Region Oncology Hospital International Department (400-880-3716) i kēia hoʻomohala holomua a hāʻawi i nā lawelawe kūkākūkā ʻoihana a me ka hoʻonohonoho ʻana i ka lāʻau no nā maʻi o ka honua.
**E pili ana iā GFH375/VS-7375**
He mea hoʻopaʻa waha, ikaika, a koho nui ʻo GFH375 i nā molekole liʻiliʻi KRAS G12D (ON/OFF) i hoʻolālā ʻia e kuhikuhi i ka hoʻololi GTP/GDP, no laila e hoʻopilikia ai i ka hoʻoulu ʻana o ke ala ma lalo a pale pono i ka hoʻonui ʻana o nā cell tumor. Ua hōʻike nā haʻawina preclinical i ka pale ʻana o ka dose-dependent i nā hiʻohiʻona e lawe ana i nā mutations KRAS G12D; Ua hōʻike pū ʻo GFH375 i ka pilikia haʻahaʻa ma waho o ka pahuhopu i ka kinase selectivity a me nā hoʻāʻo palekana.
Ua komo ʻo GenFleet i kahi hana like ʻana no ka ʻike a me ka hoʻomohala ʻana me Verastem Oncology (Nasdaq: VSTM) e hoʻolaha i ʻekolu mau papahana oncology hou e pili ana i nā maʻi kanesa i alakaʻi ʻia e ke ala RAS/MAPK. Hāʻawi ka hana like ʻana iā Verastem i kahi koho kūʻokoʻa e loaʻa ai kahi laikini no kēlā me kēia o nā hui ʻekolu ma hope o ka hoʻopau pono ʻana i nā pae i hoʻoholo mua ʻia ma kahi hoʻokolohua Phase I. I Dekemaba 2023, ua koho ʻo Verastem iā GFH375/VS-7375, kahi mea hoʻopaʻa waha KRAS G12D (ON/OFF), ma ke ʻano he papahana alakaʻi mai ka hana like ʻana, a ʻo ka laikini no GFH375 i hoʻohana ʻia i Ianuali 2025 ʻo ia ka mea mua mai kēia hana like ʻana. Hāʻawi nā laikini iā Verastem i nā kuleana hoʻomohala a me nā kuleana kālepa ma waho o Kina, ʻoiai ʻo GenFleet e mālama nei i nā kuleana ma loko o Kina.
**ʻIkepili hoʻāʻo lapaʻau Pae I/II i hōʻike ʻia ma ka 2025 ESMO Congress:**
- Ua ʻike ʻia ka emi ʻana o nā ʻeha i manaʻo ʻia he 91.5% o nā maʻi
- Ua hōʻea ka helu pane pahuhopu (ORR) i 40.7%
- ʻO ka nui o ka hoʻomalu ʻana i nā maʻi (DCR) ua like me 96.7%
- ʻO ka awelika o ke ola ʻana me ka ʻole o ka holomua (mPFS) he 5.52 mau mahina
- ʻO ka nui o ke ola ʻana me ka ʻole o ka holomua ʻana no 4 mahina he 78.2%
ʻO kēia mau ʻikepili, i loaʻa mai 59 mau maʻi me ka KRAS G12D-mutant pancreatic ductal adenocarcinoma (PDAC) holomua i loaʻa i ka lāʻau lapaʻau systemic ma mua, hōʻike ikaika i ka hana anti-tumor ikaika o GFH375 i ka maʻi kanesa pancreatic refractory.
**No ke aha e koho ai i ka ʻOihana Hoʻokele ʻĀina o ka Halemai Oncology o Beijing Hema?**
Ma ke ʻano he paionia i nā lawelawe lapaʻau honua, ua kūpaʻa ka ʻOihana Hoʻokipa ʻOncology o ka Beijing South Region i ka hāʻawi ʻana i nā mea maʻi honua me:
- Nā lawelawe kūkākūkā lapaʻau loea ʻōlelo ʻē aʻe a me nā lawelawe hoʻonohonoho manawa
- Loaʻa i nā loea oncology alakaʻi ma Kina a ma ka honua holoʻokoʻa
- Kahawai ʻōmaʻomaʻo hoʻokahi no ka mālama lapaʻau ma waena o nā palena ʻāina
Ua maopopo iā mākou no nā poʻe maʻi me ke kanesa holomua, ʻo kēlā me kēia lā keu o ke kali ʻana e lawe mai i ka pilikia nui aʻe. No laila, ua hoʻokumu mākou i nā ala hoʻokaʻaʻike honua he nui e hōʻoia i ka loaʻa ʻana o ke kākoʻo loea i ka manawa kūpono.
**E leka uila mai iā mākou i kēia lā a hoʻomaka i kāu huakaʻi o ka manaʻolana**
�� Laina wikiwiki: 400-880-3716
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ʻAʻohe mea i ka ʻāina a i ʻole ka ʻāina āu e noho nei, a i ʻole ka nui o nā koho lapaʻau āu i hoʻāʻo ai, ua mākaukau ka Beijing South Region Oncology Hospital International Department e kū pū me ʻoe i kāu hakakā ʻana i ka maʻi kanesa. ʻO ka holomua nui o GFH375 paha ke kukui āu e kali nei.
Call 400-880-3716, add us on WeChat at 17801183037, or email us at 100085_010@163.com or myimmnet@163.com.
E hui pū kākou, e hoʻoikaika no nā mea hiki ke ola hou aku.
> Nānā: ʻAʻole i ʻae ʻia ʻo GFH375 no ke kūʻai aku ʻana ma Kina nui. Manaʻo ʻia ʻo kona hoʻolālā Breakthrough Therapy e hoʻolalelale i ka hiki ke komo i nā lāʻau lapaʻau. E nānā pono ka Beijing South Region Oncology Hospital International Department i ka holomua o ka hiki ke komo i nā lāʻau lapaʻau a hāʻawi i ka ʻike e pili ana i nā lāʻau lapaʻau hou loa a me nā lawelawe hoʻonohonoho no nā poʻe maʻi kūpono. E ʻoluʻolu e hahai i ke alakaʻi a kāu kauka e pili ana i nā hoʻolālā lapaʻau kikoʻī.
Ka manawa hoʻouna: ʻApelila-10-2026