Ua hoʻolaha ʻo ImmuneOnco i ka ʻikepili palekana mua a me ka pono mai ka hoʻokolohua lapaʻau e aʻo ana iā IMM2510/AXN-2510, kahi PD-L1xVEGF Bispecific Antibody, i hui pū ʻia me Chemotherapy ma Front-line NSCLC ma Kina

Ma Iulai 31, 2025, hoʻolaha ʻo ImmuneOnco Biopharmaceuticals i ka ʻikepili palekana mua a me ka pono mai ka Phase 2 open-label, multicenter study o IMM2510 i hui pū ʻia me ka chemotherapy no nā poʻe maʻi laina mua me ka maʻi ʻaʻai māmā non-small cell holomua (NSCLC) i mālama ʻia ma Kina.

Ma Iulai 1, 2025, ua hoʻohana ʻia he 33 mau maʻi i ka lāʻau lapaʻau ma 10 mg/kg, me 21 mau maʻi i loaʻa i ka liʻiliʻi o hoʻokahi loiloi ʻana i ka maʻi puʻupuʻu (hiki ke loiloi ʻia ka pono). Ua ʻike ʻia nā pane hapa ma 62% o nā maʻi hiki ke loiloi ʻia ka pono, me nā pane hapa ma 80% (8/10) o nā maʻi me ka squamous NSCLC a me 46% (5/11) o nā maʻi me ka non-squamous NSCLC. ʻO ka hapa nui o nā maʻi hiki ke loiloi ʻia ka pono he hoʻokahi wale nō loiloi ʻana i ka maʻi puʻupuʻu ma ka ʻoki ʻikepili. Manaʻo ʻo ImmuneOnco e hōʻike i ka ʻikepili palekana a me ka pono ma ka hoʻokolohua hui pū ʻana o ka chemotherapy IMM2510 ma ka NSCLC laina mua ma kahi hālāwai kūkā lapaʻau e hiki mai ana.

Kākoʻo ka ʻikepili palekana IMM2510 i ka hoʻomohala lapaʻau hou aʻe, me ka ʻole o nā mea ʻawaʻawa e kaupalena ana i ka lāʻau i ʻike ʻia i loko o nā maʻi loiloi palekana 33. I loko o kēia mau maʻi, ʻaʻohe hanana ʻino e pili ana i ka lāʻau lapaʻau (TRAE) e alakaʻi ana i ka hōʻemi ʻana i ka lāʻau a i ʻole ka make, a hoʻokahi wale nō TRAE e alakaʻi ana i ka hoʻopau ʻana i ka lāʻau. ʻO nā TRAE Papa 3+ maʻamau he hematologic, me nā hopena lapaʻau maʻamau ʻole. ʻO nā hanana ʻino e pili pinepine ana me ka pale ʻana o VEGF (e laʻa, hypertension, proteinuria, hemoptysis) a me nā hanana ʻino e pili ana i ka pale ʻana he mea maʻamau ʻole a ma ke ʻano he haʻahaʻa, a ʻo nā hopena e pili ana i ka infusion he haʻahaʻa loa.

I kēia manawa, nui nā hoʻokolohua lapaʻau o nā ʻenehana anti-cancer hou ma Kina e ʻimi nei i nā maʻi. I ke kūkākūkā ʻana i nā lāʻau lapaʻau a me nā ʻenehana hou, hiki iā ʻoe ke hoʻokaʻaʻike aku i ka Beijing South Region Oncology Hospital International Department.

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