He maʻi ʻo Mr. X i kona mau makahiki he 40 i ʻike ʻia me ka acral melanoma. Ma hope o ke ʻoki kino radical ma hope o kona ʻike ʻia ʻana i ka makahiki 2015, ua kūpaʻa kona kūlana no ʻeiwa mau makahiki. ʻO ka mea pōʻino, ma kahi o hoʻokahi makahiki i hala aku nei, ua hoʻi hou mai kona maʻi me nā metastases i nā māmā ʻelua. ʻOiai ua loaʻa iā ia ka dissection inguinal a me pelvic lymph node a me ka lāʻau lapaʻau ʻōnaehana laina ʻekolu (me ka mālama ʻana i ka antibody PD-1 a me ka lāʻau lapaʻau NRAS mutation-targeted), ua hoʻopili nui nā puʻupuʻu i nā māmā ʻelua, ka ʻūhā, ka ʻiʻo subcutaneous o ka paia ʻōpū ʻākau, a me nā ʻiʻo erector spinae bilateral, e alakaʻi ana i ka ʻeha nui a me ka emi nui ʻana o ke ʻano o ke ola.
I kēia manawa, nui nā hoʻokolohua lapaʻau o nā ʻenehana anti-cancer hou ma Kina e ʻimi nei i nā maʻi. I ke kūkākūkā ʻana i nā lāʻau lapaʻau a me nā ʻenehana hou, hiki iā ʻoe ke hoʻokaʻaʻike aku i ka Beijing South Region Oncology Hospital International Department.
Helu Kelepona：4008803716
ʻIkepili WeChat: 17801183037
Email：myimmnet@163.com
I ka hoʻomaka ʻana o 2025, ua komo ʻo Mr. X i kahi hoʻokolohua lapaʻau o ka lāʻau lapaʻau TIL cell (GC101) a ua hoʻopau i ka hoʻokomo ʻana o ka TIL cell i ka hoʻomaka o Iune. ʻOiai ua kaumaha kona kaumaha puʻupuʻu, me ka lesion nui loa e ana ana i 62 mm, ʻeono pule ma hope o ka hoʻokomo ʻana, ua emi iho kāna mau lesions pahuhopu holoʻokoʻa ma 31.9%, me ka lesion hoʻokahi nui loa e emi ana ma kahi o 40%. Ua hōʻea ka hopena lapaʻau holoʻokoʻa i ka pane hapa (PR). ʻOi aku ka mea nui, ʻaʻole i loaʻa iā Mr. X kekahi mau hopena maikaʻi ʻole ma hope o ka lāʻau lapaʻau GC101 TIL, ʻo nā hopena ʻaoʻao maʻamau e pili ana i ka immunotherapy e like me ke anuanu a me ke kuni, i hoʻopau koke ʻia me ka lāʻau lapaʻau hōʻailona.
E pili ana iā GC101
He lāʻau lapaʻau TIL TIL kūlohelohe autologous ʻo GC101 i hoʻomohala ʻia me ka hoʻohana ʻana i ka paepae hoʻonui cell DeepTIL® ponoʻī a Juncell Therapeutics. Hiki iā DeepTIL® ke hiki i nā TIL ke ikaika loa ʻaʻole pono ka hui pū ʻana o IL-2 ma hope o ka hoʻokomo ʻana, a hiki ke haʻahaʻa ka ikaika o ka mālama mua ʻana.
ʻOiai ʻo ia ka lāʻau lapaʻau TIL mua loa e pono ai ka mālama mua ʻana me ka ikaika haʻahaʻa a ʻaʻohe inikini IL-2 ma ka honua, ua hōʻoia ʻia ʻo GC101 no kona pono lapaʻau a me ka palekana e hoʻomaikaʻi nui ana i ka palekana a me ka hiki ke loaʻa i ka lāʻau lapaʻau TIL.
E pili ana iā Melanoma
Ma Kina, ʻoi aku ka kiʻekiʻe o ka make ʻana o ka melanoma a ke piʻi nei ka nui o ka hanana i kēlā me kēia makahiki. Ke hoʻohālikelike ʻia me ʻEulopa a ʻAmelika paha, aia nā ʻokoʻa koʻikoʻi i nā ʻano o ka melanoma ma Kina: ma kahi o 90% o ka melanoma e hoʻomaka ana ma ka ʻili ma waena o ʻEulopa a me ʻAmelika. Ma ʻĀkia, ma kahi o 50% o ka melanoma e hoʻomaka ana ma ka ʻaoʻao a me 20-30% ma ka membrane mucous. I ka hoʻohālikelike ʻana, ʻoi aku ka maikaʻi ʻole o ka prognosis o ka melanoma o ke ʻano ʻaoʻao a me ka mucosal.
I kēia manawa, nui nā hoʻokolohua lapaʻau o nā ʻenehana anti-cancer hou ma Kina e ʻimi nei i nā maʻi. I ke kūkākūkā ʻana i nā lāʻau lapaʻau a me nā ʻenehana hou, hiki iā ʻoe ke hoʻokaʻaʻike aku i ka Beijing South Region Oncology Hospital International Department.
Helu Kelepona：4008803716
ʻIkepili WeChat: 17801183037
Email：myimmnet@163.com
Ka manawa hoʻouna: Aug-07-2025