Ma Malaki 10, 2026, ua hāʻawi ʻia ka B7-H3-targeting antibody-drug conjugate (ADC) YL201 hou no ka injection, i hoʻomohala ʻia e MediLink Therapeutics, i ka Breakthrough Therapy Designation e ke Center for Drug Evaluation of China's National Medical Products Administration. ʻO ka hōʻailona i koho ʻia ua hui pū ʻia me Serplulimab no ka lāʻau lapaʻau laina mua o ka maʻi ʻaʻai māmā liʻiliʻi ākea (ES-SCLC).
He ADC hou ʻo YL201 e kuhikuhi pono ana iā B7H3. Ua hoʻonui nui ʻia ka protein B7H3 ma nā pūnaewele ʻino a me nā pūnaewele hoʻomaka maʻi kanesa o nā ʻano puʻupuʻu like ʻole akā ua kaupalena ʻia ka hōʻike ʻana i loko o nā ʻiʻo maʻamau, e hōʻike ana i kona hiki ke lilo i pahuhopu lāʻau ADC. Ua hoʻomohala ʻia ʻo YL201 me ka hoʻohana ʻana i ka ʻenehana Tumor Microenvironment Activable LINker-payload (TMALIN®) a MediLink i hoʻohui ʻia me kahi antibody B7H3 kikoʻī loa. I kēia manawa, ke noiʻi ʻia nei ʻo YL201 i nā ʻano puʻupuʻu paʻa like ʻole a ua komo i nā hoʻokolohua pivotal-stage ma Small Cell Lung Cancer a me Nasopharyngeal Carcinoma ma Kina.
### ʻIkepili Lapaʻau Mana: Pono Koʻikoʻi a me ka Palekana Kūpono
I Malaki 2025, ua paʻi ka puke pai kiʻekiʻe honua ʻo *Nature Medicine* i ka ʻikepili mai ka hoʻokolohua lapaʻau Phase 1/1b o YL201 i nā poʻe maʻi me nā ʻōpū paʻa holomua. Ua hōʻike kēia haʻawina, e pili ana i 312 mau poʻe maʻi:
- **Ka Pono Holoʻokoʻa:** Ma waena o 287 mau maʻi i hiki ke loiloi ʻia, ʻo ka helu pane pahuhopu (ORR) he 40.8% kupaianaha, me 2 mau maʻi i loaʻa ka pane piha (CR) a me 115 i loaʻa ka pane hapa (PR). Ua hōʻea ka helu kaohi maʻi (DCR) i 83.6%.
- **Ka Maʻi ʻAʻai Mama Liʻiliʻi Paepae Nui (ES-SCLC):** I nā poʻe maʻi i mālama mua ʻia me ka chemotherapy platinum-based, ʻo ka ORR he 63.9%, ʻo ka DCR he 91.7%, a ʻo ka awelika o ke ola ʻole holomua (mPFS) he 6.3 mahina.
- **ʻO ke Kanesa Nasopharyngeal (NPC):** Ma waena o 70 mau maʻi, ʻo ka ORR he 48.6%, ʻo ka DCR he 92.9%, me 2 mau maʻi i loaʻa ka pane piha. ʻO ka lōʻihi waena o ka pane (mDOR) he 8.4 mau mahina.
Ua hōʻoia piha kēia mau ʻikepili i ka hana anti-tumor ikaika a me ka ʻikepili palekana hiki ke mālama ʻia o YL201 ma nā ʻano ʻano puʻupuʻu paʻa holomua, e kau ana i kahi kahua paʻa no ka noiʻi lapaʻau ma hope a me ka noi ākea.
### Ke Keʻena Hoʻokele Honua o ka Halemai Oncology o ka ʻĀpana Hema o Beijing: Kou Alahaka i ka Lāʻau Lapaʻau Honua
Ua hoʻolaʻa mau ʻia ka ʻOihana Hoʻokele o ka Halemai Oncology International o ka ʻĀpana Hema o Beijing i ka hoʻolauna ʻana i nā ʻenehana a me nā lāʻau lapaʻau e alakaʻi ana i ka honua holoʻokoʻa no ka ʻike ʻana i ka maʻi kanesa a me ka mālama ʻana. Ke hahai pono nei mākou i ka holomua o ka noiʻi hou loa a mālama i nā hana like ikaika me nā ʻoihana ʻepekema kiʻekiʻe ma ka home a ma ka honua holoʻokoʻa, e hoʻoikaika ana e hāʻawi i nā poʻe maʻi o ka honua i ka manawa kūpono i nā koho lapaʻau holomua e like me YL201.
Hiki i kā mākou hui lawelawe maʻi honua ke hāʻawi iā ʻoe i:
- **Loiloi Lapaʻau Pilikino:** E loiloi piha kahi hui multidisciplinary (MDT) i kāu mau moʻolelo lapaʻau e hoʻoholo ai inā kūpono ka lāʻau ADC no kou kūlana.
- **Ke komo maʻalahi ʻana i ka mālama:** Kōkua me ka loaʻa ʻana o nā visa no Kina, ka hoʻonohonoho ʻana i nā kūkākūkā loea, ka hoʻonohonoho ʻana i nā lawelawe wehewehe, a me ka hoʻonohonoho ʻana i ke komo ʻana i ka haukapila no kahi ʻike hopohopo ʻole.
### E Hoʻokaʻaʻike Mai Iā Mākou I Kēia Manawa No Ka ʻIke Hou Aku
Inā ʻoe a i ʻole kahi mea aloha e kū nei i nā pilikia e pili ana i ka maʻi kanesa o ka māmā liʻiliʻi ma ke kahua ākea, ka carcinoma nasopharyngeal, a i ʻole nā pūpū paʻa ʻē aʻe, a makemake ʻoe e aʻo hou aku e pili ana i ka lāʻau lapaʻau ADC hou loa a i ʻole e loiloi i nā manawa lapaʻau, e ʻoluʻolu e kelepona koke i ka Beijing South Region Oncology Hospital International Department. E pane mai kā mākou poʻe loea International Patient Services i kāu nīnau i loko o 24 mau hola.
**ʻIke Hoʻokaʻaʻike:**
- **Kelepona:** 400-880-3716��
- **WeChat:** 17801183037
- **Leka uila:**
100085_010@163.com
myimmnet@163.com
Ua maopopo iā mākou he paʻakikī ke ala o ka mālama ʻana i ka maʻi kanesa, akā ʻo kēlā me kēia holomua e hōʻike ana i ka manaʻolana hou. Makemake ka ʻOihana Hoʻokele ʻĀina ʻo Beijing South Region Oncology Hospital International e kū pū me ʻoe, e hoʻohana ana i ka ʻenehana lapaʻau loea a me ka mālama aloha a mehana, e lanakila pū i ka maʻi kanesa a apo i ka wanaʻao o ke ola.
Ka manawa hoʻouna: Malaki-24-2026