Ua kapa ʻia ʻo Carcinomaofrectum ma ke ʻano he maʻi maʻi colorectal, he maʻi maʻi maʻamau i loko o ka ʻōpū o ka ʻōpū, ʻo ka lua ka lua o ka maʻi ʻōpū a me ka esophageal, ʻo ia ka hapa maʻamau o ka maʻi maʻi colorectal (ma kahi o 60%).ʻO ka hapa nui o nā maʻi ma mua o 40 mau makahiki, a ma kahi o 15% aia ma lalo o 30 mau makahiki.ʻOi aku ka maʻamau o ke kāne, ʻo ka lakio o ke kāne i ka wahine he 2-3: 1 e like me ka nānā ʻana i ke kino, ua ʻike ʻia he ʻāpana o ka maʻi maʻi colorectal mai nā polyps rectal a i ʻole schistosomiasis;ʻo ka mumū mau o ka ʻōpū, hiki i kekahi ke hoʻoulu i ka maʻi kanesa;ʻO ka meaʻai momona a me ka protein kiʻekiʻe ka mea e hoʻonui ai i ka huna ʻana o ka cholic acid, hoʻoheheʻe ʻia ka mea hope i loko o ka polycyclic hydrocarbons unsaturated e nā anaerobes intestinal, hiki ke hoʻoulu i ka maʻi kanesa.